Effect of stored-blood transfusion on oxygen delivery in patients with sepsis

1. BACK GROUND

Stored-blood transfusion has long been a component of critical care management, particularly in patients experiencing significant blood loss or undergoing surgical procedures. In the context of sepsis, a severe and life-threatening response to infection characterized by systemic inflammation and organ dysfunction, the administration of transfusions can have profound implications for oxygen delivery and overall patient outcomes. Sepsis is associated with a complex interplay of immune responses, altered hemodynamics, and impaired microcirculation, all of which can compromise tissue perfusion and oxygenation. The primary objective of transfusion in septic patients is to restore adequate blood volume and improve oxygen-carrying capacity, thereby enhancing tissue oxygen delivery. However, the effects of stored-blood transfusion on patients with sepsis are not straightforward. Blood stored for transfusion undergoes several biochemical and physiological changes over time,
…