농약

5.6.3 유기인계 살충제  최초: tetraethyl pyrophosphate (TEPP): very effective  단점: highly toxic to mammals LD50 mice (oral) 2 mg/kg unstable in water  대체품: parathion, paraoxon  장점: broad spectrum; low volatility; not persistent; stable in water  단점: high mammalian toxicity 저독성 대체품: fenitrothion (ref. p594 표 5.6.1)  mechanism of toxic action: AChE inhibition  toxic sign: Ach accumulation에 기인  Ach의 muscarine 증상: 구토, 복통, 설사, 배변, 축동, 유연, 유루, 기관지수축, 기관지분비 증대  Ach의 nicotine 증상: 피로, 근력저하, 전신성 경련, 호흡곤란, cyanosis  해독제: atropine (cholinergic inhibitor), 2-PAM (pralidoxime) (AChE 저해작용을 해제) parathion → paraoxon [metabolic activation; metabolic intoxication] ① metabolic activation (toxification) paraoxon: AchE 저해작용 ② ③ ④ ⑤ : metabolic detoxification AchE 저해작용 없음 ⑤ is the main detoxification process catalyzed by esterase found in almost every tissue. 5.6.5 유기염소계 제초제와 TCDD  Chlorophenoxy compo…
…