Vitamin E Vitamin C and Carotenoids as Nutritional Antioxidants

Oxidative Stress - endogenous reactive oxygen species ; damage DNA, protein, carbohydrates, lipids --> 병유발 e.g., hydroxyl radical, superoxide anion radical, hydrogen peroxide, 1O2, hypochlorite, nitric oxide radical, peroxynitrite - a major site of production for reactive oxygen species ; respiratory chain --> superoxide radical anion 등이 생성됨 (antimicrobial defence, inflamation, photobiological reaction 등에 의해서도 생성됨) - `Oxidative stress`는 prooxidant-antioxidant balance를 깸 ; normal aerobic steady-state가 깨지면서 product에 damage ! - antioxidant 섭취가 불충분하면 oxidative stress 생길수도 있다. - 주요 prooxidant의 half life hydroxyl radicals ; nanoseconds peroxyl radicals, nitric oxide, peroxynitrite ; seconds - oxydative stress 극복 기작 ① prevention ② interception ; antioxidant agent 농도가 높아야 작동 ③ repair