Pathophysiology and therapy of pruritus in allergic and atopic diseases

_SLIDE_1_ Pathophysiology and therapy of pruritus in allergic and atopic diseases J. Buddenkotte1 & M. Steinhoff2 1Deparment of Dermatology, Boltzmann Institute for Cell- and Immunobiology of the Skin, University Hospital Mu¨ nster, Mu¨ nster, Germany; 2Depatments of Dermatology and Surgery, University of California, San Francisco, CA, USA (1)Deparment of Dermatology, Boltzmann Institute for Cell- and Immunobiology of the Skin, University Hospital Mu¨ nster, Mu¨ nster, Germany; (2)Depatments of Dermatology and Surgery, University of California, San Francisco, CA, USA _SLIDE_2_ Itch transmission by the nervous system _SLIDE_3_ The skin barrier protect from the outside _SLIDE_4_ Pruritus An unpleasant sensation to scratch constitutes an essential feature of atopic dermatitis low-intensity pain _SLIDE_5_ Pruritus _SLIDE_6_ Pruritus To relay itch information to different cerebric areas is the specific function of a subpopulation of the dense nerval network …
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