세포

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THE NOBEL PRIZE IN
PHYSIOLOGY OR MEDICINE
2008
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Human Papilloma Viruse(HPV)
“Human papilloma viruses causing cervical cancer”
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Human papilloma virus (HPV): the virus behind cervical cancer is exposed
Harald zur Hausen described how he had tried to find herpes viruses in tumors with no success.
He assumed that if the tumor cells contained a virus that caused cancer, they would have viral DNA incorporated into their own genes.
To track down this viral DNA he constructed short, single-stranded DNA segments and used them as “bait” to fish out matching viral DNA from the tumor cells.
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A patient fisherman
How it was done
Harald zur Hausen worked for ten years to prove his hypothesis.
He fished for HPV gene sequences in tumor cells using hooks baited with DNA encoding previously known forms of HPV.
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Nine cases out of ten r…