Secondary metabolite

PURPOSE
이차 대사산물을 알고 HPLC를 통해 물질의 유무를 확인한다.
Introduction

1. Lovastatin

Monacolin K inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis, and are effective in lowering plasma cholesterol levels in human as well as in animals.
• Fungi (Monascus, Aspergillus)
• Secondary metabolite
• Cholesterol synthesis inhibition
• Monacolin K, mevinolin
☞ Regulation of cholesterol biosynthesis balances synthesis with dietary uptake

2. Cordycepin

Cordyccpin, a nucleoside analogue 3`-deoxyadenosine
Extracted from Cordyceps militaris, and was found to be present in small
amounts in Cordyceps sinensis.

3. HPLC(High-performanace liquid chromatography)

크로마토그래피란 짧게 말해서 색소물질을 흡착제에 의해서 분리하는 방법이다.
또 다른말로는 색층분석(色層分析)이라고도 한다. 1906년…(생략)