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산화제는 산소의 불안정한 대사산물로서 강력한 산화성 작용을 지니고 있으며, 과산화물(02-), 과산화수소 및 수산기( OH⋅) 등이 있는데 패혈증, 허혈-재관류, 화상 등의 질환에서 많이 분비되는 것으로 알려져 있다(Cross et al., 1987; Heffner & Repine, 1989; Reilly et al., 1991). 이들 물질들은 세포막의 구성성분인 지질을 과산화시켜서 세포막의 손상과 더불어 세포내 기능상실을 유발시킨다. 이러한 산화제에 의한 폐조직의 지질과산화는 화상을 비롯한 여러 동물실험모델에서 증명되었다(Jin et al., 1986; Demling & Lalonde, 1990; Demling et al., 1991). Paraquat(1,1`-dimethyl-4, 4-bipyridylium dichloride)는 1958년 영국에서 처음으로 제초제로 사용된 이래 전세계적으로 널리 사용되어져 왔던 약제로, 사람과 동물이 중독시 독성이 치명적인 것으로 알려져 있다. Paraquat를 음독시 문제가 되는 것은 치료제로서 특별한 해독제가 없다는 사실과 음독 후 조기의 적극적인 치료, 예를 들면 장에서의 흡수를 줄이기 위하여 위장세척, 구토, 활성탄 투여 등의 방법과, 흡수된 혈중내의 paraquat을 제거하기 위하여 복막투석, 혈액투석, hemoperfusion,…(생략)
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폐와 간조직의 산화성 손상에 대한 Deferoxamine의 항~.hwp
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