5.6.3 À¯±âÀÎ°è »ìÃæÁ¦
ÃÖÃÊ: tetraethyl pyrophosphate (TEPP): very effective
´ÜÁ¡: highly toxic to mammals LD50 mice (oral) 2 mg/kg
unstable in water
´ëüǰ: parathion, paraoxon
ÀåÁ¡: broad spectrum; low volatility; not persistent; stable in water
´ÜÁ¡: high mammalian toxicity
Àúµ¶¼º ´ëüǰ: fenitrothion (ref. p594 Ç¥ 5.6.1)
mechanism of toxic action: AChE inhibition
toxic sign: Ach accumulation¿¡ ±âÀÎ
AchÀÇ muscarine Áõ»ó: ±¸Åä, º¹Åë, ¼³»ç, ¹èº¯, Ãൿ, À¯¿¬, À¯·ç, ±â°üÁö¼öÃà, ±â°üÁöºÐºñ Áõ´ë
AchÀÇ nicotine Áõ»ó: ÇÇ·Î, ±Ù·ÂÀúÇÏ, Àü½Å¼º °æ·Ã, È£Èí°ï¶õ, cyanosis
Çص¶Á¦: atropine (cholinergic inhibitor),
2-PAM (pralidoxime) (AChE ÀúÇØÀÛ¿ëÀ» ÇØÁ¦)
parathion ¡æ paraoxon [metabolic activation; metabolic intoxication]
¨ç metabolic activation (toxification)
paraoxon: AchE ÀúÇØÀÛ¿ë
¨è ¨é ¨ê ¨ë : metabolic detoxification
A¡¦(»ý·«)
¨ë is the main detoxification process catalyzed by esterase found in almost every tissue.
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