Vitamin E Vitamin C and Carotenoids as Nutritional Antioxidants

Oxidative Stress
- endogenous reactive oxygen species
; damage DNA, protein, carbohydrates, lipids --> 병유발
e.g., hydroxyl radical, superoxide anion radical, hydrogen peroxide, 1O2, hypochlorite, nitric oxide
radical, peroxynitrite
- a major site of production for reactive oxygen species
; respiratory chain --> superoxide radical anion 등이 생성됨
(antimicrobial defence, inflamation, photobiological reaction 등에 의해서도 생성됨)
- `Oxidative stress`는 prooxidant-antioxidant balance를 깸
; normal aerobic steady-state가 깨지면서 product에 damage !
- antioxidant 섭취가 불충분하면 oxidative stress 생길수도 있다.
- 주요 prooxidant의 half life
hydroxyl radicals ; nanoseconds
peroxyl radicals, nitric oxide, peroxynitrite ; seconds
- oxydative stress 극복 기작

① prevention

② interception ; antioxidant agent 농도가 높아야 작동

③ repair